Insulin signalling in human adipocytes –mechanisms of - DiVA

Influence of insulin on glucose metabolism and lipolysis in

The Rho family member GTPase TC10 has been shown to play a role in insulin-stimulated glucose uptake and translocation of the glucose transporter GLUT4 in 3T3L1 adipocytes (5, 6). In this signaling cascade, the insulin receptor and TC10 reside constitutively in lipid raft microdomains of the plasma membrane. Furthermore, the data indicate that the cellular content of GLUT4 is the rate‐limiting factor in mediating maximal insulinstimulated glucose uptake in GLUT4(+/–) adipocytes.—Li, J., Houseknecht, K. L., Stenbit, A. E., Katz, E. B., Charron, M. J. Reduced glucose uptake precedes insulin signaling defects in adipocytes from heterozygous Insulin resistance results in decreased insulin-stimulated glucose transport into skeletal muscle and adipocyte tissue . Keywords Glucose Uptake Chronic Hyperglycemia Newborn Calf Serum Basal Glucose Uptake Mature White Adipocyte Some of these novel lipids enhance the effect of insulin on glucose uptake in adipocytes and augment glucose‐stimulated GLP1 secretion from entero‐endocrine cells and insulin secretion by pancreatic beta cells (Fig. 4) 36.

SIRT1 depletion inhibited insulin-stimulated glucose uptake and GLUT4 7 Jun 2017 We show that insulin-stimulated Glut4-mediated glucose uptake phosphorylations in insulin-regulated glucose uptake by adipocytes and 1 Aug 2011 Effects of hyperthyroidism on the sensitivity of glycolysis and glycogen synthesis to insulin in the soleus muscle of the rat. Biochem J. 1988; 253: 10 Nov 2014 Insulin-stimulated glucose uptake occurs primarily through GLUT4 translocation in both brown and white adipocytes (Dallner et al., 2006; Huang 8 Jul 2015 The NRLP3 inflammasome enhances insulin resistance by triggering inflammation in adipose tissue in subjects with obesity (16,17). In this study, This adipokine plays many different physiological roles such as promoting insulin sensitivity and regulating lipid metabolism10. Research indicates that insulin 18 Sep 2018 stromovascular cells, T cells, TNF, tumor necrosis factors, Type 2 diabetes, Type II diabetes, WAT, WBC, weight loss, white adipose tissue, 30 Aug 2017 and differentiated adipocytes to determine the insulin-like and insulin of insulin to target receptor or increasing glucose uptake in adipocyte av A Danielsson · 2007 · Citerat av 5 — After a meal the blood glucose level is raised, which leads to an increased secretion of insulin in the blood.

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There are five types of insulin. If you have to take insulin to treat diabetes, there’s good news: You have choices.There are five types of insulin.

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Basal glucose uptake in adipocytes treated with 5, 10, or 20μM DIM significantly increased by ∼1.4‐, 1.8‐, and 3.2‐fold, respectively, compared with controls. In the absence of DIM, insulin‐stimulated glucose uptake of adipocytes was increased by approximately 1.8‐fold compared with the basal level. 2018-05-01 · Res increases glucose uptake of insulin-resistant 3T3-L1 adipocytes. We first established the insulin-resistant model in 3T3-L1 adipocytes treated with dexamethasone (Dex). Without Dex treatment, the cellular glucose uptake was increased significantly in response of insulin stimulation (Fig. S1A).

S1A). chemerin potentiated insulin-stimulated glucose uptake concom-itant with enhanced insulin signaling in the 3T3-L1 adipocytes. These data establish that chemerin is a novel adipokine that reg-ulates adipocyte function. 2008 FederationofEuropeanBiochemicalSocieties.Published by Elsevier B.V. All rights reserved. Keywords: Adipokine; Chemerin; Insulin signaling; Adipocyte 2011-09-26 · The increase in insulin-stimulated 2-deoxyglucose uptake was significantly higher in CETP-3T3-L1 adipocytes, as compared with the two control groups (3T3-L1 and His-3T3-L1 cells) (p < 0.01). Download : Download full-size image; Fig. 4.
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The purpose of this study was to test a hypothesis that T3 promotes glucose uptake via enhancing insulin‐induced Akt phosphorylation and VAMP2 translocation in 3T3‐L1 adipocytes.

T3 significantly enhanced insulin‐induced phosphorylation of Akt, cytoplasma to cell membrane translocations of vesicle‐associated membrane protein 2 (VAMP2) and glucose transporter 4 (GLUT4), and glucose gained wide acceptance as critical components in insulin-stimulated glucose uptake, the MAPK pathway does not have an established role in mediating the metabolic effects of insulin in adipocytes. 2014-02-14 · Insulin-induced glucose uptake was completely cancelled by pretreatment of the adipocytes with the insulin receptor inhibitor AG1024; however, AG1024 could not block the effect of CE . Intriguingly, insulin or CE increased the phosphorylation of Akt at its Ser 473, and this increase was significantly blocked by AG1024 . T1 - Role of PDE3B in insulin-induced glucose uptake, GLUT-4 translocation and lipogenesis in primary rat adipocytes.
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AU - Oknianska, Alina. AU - Manganiello, Vincent Previous study has revealed that chromium malate could improve insulin resistance and the regulation of fasting blood glucose in type 2 diabetic rats. This study was designed to investigate the effect of chromium malate on hypoglycemic and improve insulin resistance activities in 3T3-L1 adipocytes with insulin resi Mechanical stretch-induced extracellular vesicles improved insulin-stimulated glucose uptake in myotubes and adipocytes Abstract # 451 Insulin-Mediated Glucose Uptake in Brown Adipocytes Isolated From GLUT4myc-Expressing Mice Daniel Konrad, 1,2 Philip J. Bilan, 1 Zafar Nawaz, 1 Gary Sweeney, Wenyan Niu, Zhi Liu, 2005-10-01 · However, in insulin-stimulated rat adipocytes, glucose transport is inhibited by isoproterenol in a cAMP-PKA-independent manner (11, 17).

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Curcumin is a direct inhibitor of glucose transport in adipocytes

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Furthermore, the data indicate that the cellular content of GLUT4 is the rate‐limiting factor in mediating maximal insulinstimulated glucose uptake in GLUT4(+/–) adipocytes.—Li, J., Houseknecht, K. L., Stenbit, A. E., Katz, E. B., Charron, M. J. Reduced glucose uptake precedes insulin signaling defects in adipocytes from heterozygous Insulin resistance results in decreased insulin-stimulated glucose transport into skeletal muscle and adipocyte tissue . Keywords Glucose Uptake Chronic Hyperglycemia Newborn Calf Serum Basal Glucose Uptake Mature White Adipocyte Some of these novel lipids enhance the effect of insulin on glucose uptake in adipocytes and augment glucose‐stimulated GLP1 secretion from entero‐endocrine cells and insulin secretion by pancreatic beta cells (Fig.

Since pharmacological as well as genetic inhibition of Panx1 in adipocytes resulted in blunted insulin-stimulated glucose uptake, we hypothesized that Panx1-mediated ATP release was responsible for the effect. Basal glucose uptake in adipocytes treated with 5, 10, or 20μM DIM significantly increased by ∼1.4‐, 1.8‐, and 3.2‐fold, respectively, compared with controls. In the absence of DIM, insulin‐stimulated glucose uptake of adipocytes was increased by approximately 1.8‐fold compared with the basal level.